The Effects of Zinc Sulfate Supplementation on Serum Copeptin, C-Reactive Protein and Metabolic Markers in Zinc-Deficient Diabetic Patients on Hemodialysis: A Randomized, Double-Blind, Placebo-Controlled Trial

We aimed to investigate the association between zinc (Zn) supplementation and serum levels of copeptin, high-sensitive C-reactive protein (hs-CRP), glycemic control, anthropometric parameters renal function in Zn -deficient diabetic hemodialysis patients (DHPs). This randomized, double-blind, placebo-controlled trial (RCT) was conducted on 46 DHPs with Zn-deficiency. The supplement group (n = 21) received a 220-mg/day sulfate capsule (containing 50 mg Zn), control 25) placebo (220 corn starch), for 8 weeks. Fasting, predialysis blood samples were taken at baseline after weeks assess fasting glucose (FBG), insulin, urea nitrogen (BUN), creatinine (Cr) concentrations, homoeostatic model assessment (HOMA-IR) quantitative insulin-sensitivity check index (QUICKI). Compared controls, copeptin (P < 0.001), hs-CRP BUN Cr FBG 0.001) levels, BMI body weight significantly affected following ZnSO4 In contrast, QUICKI 0.57), HOMA-IR 0.60), insulin 0.55) not comparison receiving placebo. appears have favorable effects hs-CRP, FBG, Zn-deficient DHPs. Iranian Registry Clinical Trials Identifier: IRCT20190806044461N1